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Hematology/Oncology Secrets: A Comprehensive Guide for Students and Practitioners
Hematology/Oncology Secrets is a book that covers the full range of hematology and oncology topics, from basic concepts to advanced techniques. It is written in a question-and-answer format that provides concise and practical information, as well as insights, pearls, and "secrets" from experts in the field. The book is divided into five major sections: General Concepts, General Hematology, Malignant Hematology, Care of the Cancer Patient, and Solid Tumors. Each section contains chapters on specific topics, such as evaluation of anemia, iron deficiency anemia, acute leukemia, Hodgkin's disease, carcinogenesis, infectious complications of chemotherapy, paraneoplastic neurologic syndromes, breast cancer, lung cancer, testicular cancer, and more. The book also includes tables, figures, and examples to illustrate key points and concepts.
Hematology/Oncology Secrets is a valuable resource for students and practitioners who want to learn more about hematology and oncology, prepare for board exams, or update their knowledge and skills. The book is available in both print and digital formats. The print version can be purchased from various online retailers or bookstores. The digital version can be downloaded for free from the Internet Archive[^1^], Google Books[^2^], or WorldCat[^3^]. However, the quality and completeness of the digital version may vary depending on the source. Therefore, it is recommended to check the original print version for accuracy and reliability.
In this article, we will review some of the chapters from each section of Hematology/Oncology Secrets and highlight some of the key points and "secrets" that they contain. We will also provide some references for further reading and learning.
This section covers the general principles and concepts that are essential for understanding hematology and oncology. It includes chapters on evaluation of common clinical scenarios, such as palpable breast mass, lung mass, testicular mass, intracranial mass, anemia, bleeding diathesis, adenopathy, leukocytosis, and more. It also covers topics such as carcinogenesis, cancer in the elderly, prevention and management of common toxicities, infectious complications of chemotherapy, biologic therapy of cancer, therapeutics, paraneoplastic neurologic syndromes, and more.
Some of the "secrets" from this section are:
The most common cause of a palpable breast mass in women under 40 years old is fibrocystic disease.
The most common cause of a lung mass in smokers is bronchogenic carcinoma.
The most common cause of a testicular mass in young men is germ cell tumor.
The most common cause of an intracranial mass in adults is metastatic tumor.
The most common cause of anemia in the United States is iron deficiency.
The most common cause of bleeding diathesis in adults is acquired factor deficiency.
The most common cause of adenopathy in adults is reactive lymphadenitis.
The most common cause of leukocytosis in adults is infection.
Carcinogenesis is a multistep process that involves initiation, promotion, progression, and metastasis.
Cancer in the elderly is more prevalent, more heterogeneous, and less responsive to treatment than in younger patients.
The most common toxicities of chemotherapy are myelosuppression, nausea and vomiting, mucositis, alopecia, and neurotoxicity.
The most common infectious complications of chemotherapy are bacterial infections (especially gram-negative), fungal infections (especially Candida and Aspergillus), and viral infections (especially herpes simplex and varicella zoster).
Biologic therapy of cancer involves the use of agents that modulate the immune system or target specific molecules on cancer cells. Examples include monoclonal antibodies, cytokines, vaccines, and gene therapy.
Therapeutics is the science and art of choosing and using drugs to treat diseases. It involves pharmacokinetics (what the body does to the drug), pharmacodynamics (what the drug does to the body), pharmacogenetics (how genetic factors affect drug response), and pharmacoeconomics (how cost-effectiveness influences drug choice).
Paraneoplastic neurologic syndromes are rare disorders that result from an immune-mediated response to a tumor antigen that cross-reacts with neural tissue. They can affect any part of the nervous system and can precede or follow the diagnosis of cancer. Examples include Lambert-Eaton myasthenic syndrome, paraneoplastic cerebellar degeneration, paraneoplastic encephalomyelitis, and paraneoplastic opsoclonus-myoclonus.
For further reading and learning on general concepts, we recommend the following references:
Wood ME, Philips GK. Hematology/Oncology Secrets. 3rd ed. Philadelphia: Elsevier; 2003.
DeVita VT Jr., Lawrence TS, Rosenberg SA. Cancer: Principles & Practice of Oncology. 11th ed. Philadelphia: Wolters Kluwer; 2018.
Hoffman R, Benz EJ Jr., Silberstein LE, et al. Hematology: Basic Principles and Practice. 7th ed. Philadelphia: Elsevier; 2018. 061ffe29dd